Depressive Disorder, also known as depression, is related to dysthymic disorder and atypical depressive disorder, and has symptoms including affective symptoms, behavioral symptoms and schizophrenic language. An important gene associated with Depressive Disorder is NOTCH3 (Notch Receptor 3), and among its related pathways/superpathways are Signal Transduction and CREB Pathway. The drugs Agomelatine and Hydroxocobalamin have been mentioned in the context of this disorder. Affiliated tissues include brain and prefrontal cortex, and related phenotypes are Decreased viability and nervous system