Dentin Caries, also known as dental caries extending into dentine, is related to root caries and dental caries. An important gene associated with Dentin Caries is MMP8 (Matrix Metallopeptidase 8), and among its related pathways/superpathways are Collagen chain trimerization and Development Dopamine D2 receptor transactivation of EGFR. The drugs Sodium fluoride and Fluorides have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotype is skeleton.