Dental Fluorosis

Dental Fluorosis, also known as mottled teeth, is related to dental caries and hypercementosis, and has symptoms including toothache An important gene associated with Dental Fluorosis is AMBN (Ameloblastin), and among its related pathways/superpathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Development_Hedgehog and PTH signaling pathways in bone and cartilage development. The drugs Fluorides and Protective Agents have been mentioned in the context of this disorder. Affiliated tissues include bone and thyroid, and related phenotypes are craniofacial and skeleton