Delayed Puberty, Self-Limited, also known as constitutional delay of puberty, is related to hypogonadism and hypogonadotropic hypogonadism 7 with or without anosmia. An important gene associated with Delayed Puberty, Self-Limited is LGR4 (Leucine Rich Repeat Containing G Protein-Coupled Receptor 4). Affiliated tissues include breast and bone, and related phenotypes are delayed skeletal maturation and delayed puberty