Diffuse Mesangial Sclerosis, also known as mesangial sclerosis, diffuse, is related to nephrotic syndrome, type 4 and denys-drash syndrome. An important gene associated with Diffuse Mesangial Sclerosis is WT1 (WT1 Transcription Factor), and among its related pathways/superpathways are ERK Signaling and Signal Transduction. Affiliated tissues include kidney and eye, and related phenotypes are Increased hepcidin::fluc mRNA expression and renal/urinary system