Diffuse Scleroderma, also known as diffuse systemic sclerosis, is related to diffuse cutaneous systemic sclerosis and scleroderma, familial progressive, and has symptoms including exanthema, pruritus and hidebound skin. An important gene associated with Diffuse Scleroderma is EXOSC10 (Exosome Component 10). The drugs Tadalafil and Acetylsalicylic acid have been mentioned in the context of this disorder. Affiliated tissues include lung and skin.