Diabetic Polyneuropathy, also known as diabetes mellitus with polyneuropathy, is related to polyneuropathy and autonomic neuropathy. An important gene associated with Diabetic Polyneuropathy is AKR1B1 (Aldo-Keto Reductase Family 1 Member B), and among its related pathways/superpathways are Signal Transduction and Activation of cAMP-Dependent PKA. The drugs Acetylcholine and Lipoic acid have been mentioned in the context of this disorder. Affiliated tissues include spinal cord and dorsal root ganglion, and related phenotypes are Reduced mammosphere formation and nervous system