Cylindromatosis, Familial, also known as ancell-spiegler cylindromas, is related to brooke-spiegler syndrome and trichoepithelioma, multiple familial, 1. An important gene associated with Cylindromatosis, Familial is CYLD (CYLD Lysine 63 Deubiquitinase). Affiliated tissues include skin and salivary gland, and related phenotypes are subcutaneous nodule and telangiectasia of the skin