Cyclic Vomiting Syndrome, also known as cyclical vomiting syndrome, is related to migraine with or without aura 1 and mosaic trisomy 2, and has symptoms including abdominal pain, lethargy and nausea. An important gene associated with Cyclic Vomiting Syndrome is MT-TL1 (Mitochondrially Encoded TRNA-Leu (UUA/G) 1). The drugs Topiramate and Hypoglycemic Agents have been mentioned in the context of this disorder. Affiliated tissues include skin and brain, and related phenotypes are vomiting and intellectual disability