Cushing Syndrome Due to Bilateral Macronodular Adrenocortical Disease, also known as cushing syndrome due to primary bilateral macronodular adrenal hyperplasia, is related to acth-independent macronodular adrenal hyperplasia and primary pigmented nodular adrenocortical disease. An important gene associated with Cushing Syndrome Due to Bilateral Macronodular Adrenocortical Disease is ARMC5 (Armadillo Repeat Containing 5). Affiliated tissues include pituitary, and related phenotypes are macronodular adrenal hyperplasia and moon facies