Critical Covid-19 is related to non-severe covid-19 and adult respiratory distress syndrome. An important gene associated with Critical Covid-19 is ACE2 (Angiotensin Converting Enzyme 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Sargramostim and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include lung and kidney, and related phenotypes are homeostasis/metabolism and immune system