Creutzfeldt-Jakob Disease, also known as variant creutzfeldt-jakob disease, is related to gerstmann-straussler disease and normal pressure hydrocephalus, and has symptoms including back pain, headache and hemiparesis. An important gene associated with Creutzfeldt-Jakob Disease is PRNP (Prion Protein (Kanno Blood Group)), and among its related pathways/superpathways are Neuroscience and Neural Stem Cells and Lineage-specific Markers. The drugs Coal tar and Quinacrine have been mentioned in the context of this disorder. Affiliated tissues include brain and spinal cord, and related phenotypes are seizure and abnormal pyramidal sign