Crohn's Disease, also known as crohn disease, is related to ulcerative colitis and inflammatory bowel disease, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Crohn's Disease is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Rebamipide and Prucalopride have been mentioned in the context of this disorder. Affiliated tissues include Bone, Adipose and colon, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and homeostasis/metabolism