Cerebellar Ataxia, Neuropathy, and Vestibular Areflexia Syndrome (CANVAS)

Cerebellar Ataxia, Neuropathy, and Vestibular Areflexia Syndrome, also known as canvas, is related to aceruloplasminemia and neuropathy, and has symptoms including cerebellar ataxia, gait ataxia and imbalance. An important gene associated with Cerebellar Ataxia, Neuropathy, and Vestibular Areflexia Syndrome is RFC1 (Replication Factor C Subunit 1), and among its related pathways/superpathways is Assembly of the pre-replicative complex. The drugs Fondaparinux and Warfarin have been mentioned in the context of this disorder. Affiliated tissues include brain and eye, and related phenotypes are dysarthria and delayed speech and language development