Cerebral Arteriopathy, Autosomal Dominant, with Subcortical Infarcts and Leukoencephalopathy, Type 1 (CADASIL1)

Alias:

Cadasil

Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy

Hereditary Multi-Infarct Dementia

Cerebral Arteriopathy with Subcortical Infarcts and Leukoencephalopathy

Familial Vascular Leukoencephalopathy

Cadasil Syndrome

Cadasil 1

Cadasil1

Casil

Autosomal Dominant Cerebral Arteriopathy with Subcortical Infarcts and Leukoencephalopathy Type 1

Cerebral Arteriopathy, Autosomal Dominant, with Subcortical Infarcts and Leukoencephalopathy, 1

Arteriopathy, Cerebral, Autosomal Dominant, with Subcortical Infarcts and Leukoencephalopathy

Cerebral Arteriopathy with Subcortical Infarcts and Leukoencephalopathy, Autosomal Dominant

Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts Leukoencephalopathy

Cerebral Autosomal Dominant Arteriopathy-Subcortical Infarcts-Leukoencephalopathy

Cerebral Autosomal Dominant Arteriopathy-Subcortical Infarcts-Leukoencephalopath

Cerebral Arteriopathy with Subcortical Infarcts and Leukoencephalopathy 1

Hereditary Dementia, Multi-Infarct Type

Dementia, Hereditary Multiinfarct Type

Dementia Hereditary Multi-Infarct Type

Dementia Hereditary Multiinfarct Type

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Basic Information

Medical Symptom

Gene & Mutation

Related Drugs

Disease Model

References Literature

Cerebral Arteriopathy, Autosomal Dominant, with Subcortical Infarcts and Leukoencephalopathy, Type 1, also known as cadasil, is related to brain small vessel disease 1 and cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2. An important gene associated with Cerebral Arteriopathy, Autosomal Dominant, with Subcortical Infarcts and Leukoencephalopathy, Type 1 is NOTCH3 (Notch Receptor 3), and among its related pathways/superpathways are Signal Transduction and PAK Pathway. The drugs Dabigatran and Donepezil have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle and brain, and related phenotypes are leukoencephalopathy and abnormal cerebral white matter morphology

Related ID：

MALACARDS：CRB175

OMIM：125310

MESH：D046589