Central Congenital Hypothyroidism, also known as secondary hypothyroidism, is related to hypothyroidism, central, with testicular enlargement and isolated thyroid-stimulating hormone deficiency. An important gene associated with Central Congenital Hypothyroidism is TSHB (Thyroid Stimulating Hormone Subunit Beta). The drugs Sodium citrate and Citric acid have been mentioned in the context of this disorder. Affiliated tissues include thyroid and pituitary.