Cannabis Abuse, also known as marijuana abuse, is related to polysubstance abuse and drug psychosis. An important gene associated with Cannabis Abuse is CNR1 (Cannabinoid Receptor 1), and among its related pathways/superpathways are Signal Transduction and Transmission across Chemical Synapses. The drugs Methadone and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include brain and prefrontal cortex, and related phenotypes are nervous system and homeostasis/metabolism