Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal Nevi (CLOVE)

Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal Nevi, also known as cloves syndrome, is related to rapidly involuting congenital hemangioma and capillary malformations, congenital, and has symptoms including angina pectoris, back pain and chest pain. An important gene associated with Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal Nevi is PIK3CA (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha), and among its related pathways/superpathways are Innate Immune System and Infectious disease. The drugs Temsirolimus and Remifentanil have been mentioned in the context of this disorder. Affiliated tissues include skin and bone, and related phenotypes are hemihypertrophy and tethered cord