Coumarin Resistance, also known as warfarin sensitivity, is related to vitamin k deficiency bleeding and pulmonary embolism. An important gene associated with Coumarin Resistance is VKORC1 (Vitamin K Epoxide Reductase Complex Subunit 1), and among its related pathways/superpathways are Metabolism and Metapathway biotransformation Phase I and II. Affiliated tissues include heart and brain, and related phenotypes are abnormality of blood and blood-forming tissues and homeostasis/metabolism