Complement Hyperactivation, Angiopathic Thrombosis, and Protein-Losing Enteropathy, also known as chaple, is related to congenital disorder of glycosylation, type ib and congenital diarrhea 7 with exudative enteropathy. An important gene associated with Complement Hyperactivation, Angiopathic Thrombosis, and Protein-Losing Enteropathy is CD55 (CD55 Molecule (Cromer Blood Group)). The drugs Abciximab and Alprostadil have been mentioned in the context of this disorder. Affiliated tissues include liver and heart, and related phenotypes are malabsorption and decreased circulating antibody level