Combined Cellular and Humoral Immune Defects with Granulomas (CCHIDG)

Combined Cellular and Humoral Immune Defects with Granulomas, also known as combined immunodeficiency due to rag 1/2 deficiency, is related to severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative and severe combined immunodeficiency with sensitivity to ionizing radiation. An important gene associated with Combined Cellular and Humoral Immune Defects with Granulomas is RAG2 (Recombination Activating 2), and among its related pathways/superpathways is Interleukin-7 signaling. Affiliated tissues include skin and t cells, and related phenotypes are recurrent respiratory infections and decreased circulating igg level