Class I Glucose-6-Phosphate Dehydrogenase Deficiency, also known as severe hemolytic anemia due to g6pd deficiency, is related to glucosephosphate dehydrogenase deficiency and anemia, nonspherocytic hemolytic, due to g6pd deficiency. An important gene associated with Class I Glucose-6-Phosphate Dehydrogenase Deficiency is G6PD (Glucose-6-Phosphate Dehydrogenase), and among its related pathways/superpathways is ATM signaling in development and disease. Affiliated tissues include heart and skin.