Classic Progressive Supranuclear Palsy Syndrome, also known as steele-richardson-olszewski disease, is related to atherosclerosis-deafness-diabetes-epilepsy-nephropathy syndrome and atherosclerosis, premature, with deafness, nephropathy, diabetes mellitus, photomyoclonus, and degenerative neurologic disease, and has symptoms including back pain, headache and muscle rigidity. An important gene associated with Classic Progressive Supranuclear Palsy Syndrome is MAPT (Microtubule Associated Protein Tau). The drugs Zoledronic acid and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include eye and bone marrow, and related phenotypes are mental deterioration and postural instability