Cluster Headache, also known as headache, cluster, is related to headache and migraine with aura, and has symptoms including headache and recurrent paroxysmal headache. An important gene associated with Cluster Headache is HCRTR2 (Hypocretin Receptor 2), and among its related pathways/superpathways are Signal Transduction and GPCR downstream signalling. The drugs Sumatriptan and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye and brain.