Colonic Pseudo-Obstruction, also known as primary chronic pseudo-obstruction of colon, is related to volvulus of midgut and intestinal obstruction. An important gene associated with Colonic Pseudo-Obstruction is ACHE (Acetylcholinesterase (Yt Blood Group)), and among its related pathways/superpathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors). The drugs Neostigmine and Cholinergic Agents have been mentioned in the context of this disorder. Affiliated tissues include colon and smooth muscle, and related phenotypes are muscle and homeostasis/metabolism