Culler-Jones Syndrome (CJS)

Culler-Jones Syndrome, also known as postaxial polydactyly-anterior pituitary anomalies-facial dysmorphism syndrome, is related to holoprosencephaly 1 and polydactyly. An important gene associated with Culler-Jones Syndrome is GLI2 (GLI Family Zinc Finger 2), and among its related pathways/superpathways are Signal Transduction and Signaling by Hedgehog. Affiliated tissues include pituitary and bone, and related phenotypes are global developmental delay and cleft palate