Clubfoot

Clubfoot, also known as congenital talipes equinovarus, is related to arthrogryposis, distal, type 7 and arthrogryposis, distal, type 1a. An important gene associated with Clubfoot is PITX1 (Paired Like Homeodomain 1), and among its related pathways/superpathways are Cardiac conduction and Striated muscle contraction pathway. The drugs Clonidine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include bone and skeletal muscle, and related phenotypes are growth/size/body region and limbs/digits/tail