Chronic Recurrent Multifocal Osteomyelitis 2, with Periostitis and Pustulosis, also known as sterile multifocal osteomyelitis with periostitis and pustulosis, is related to chronic nonbacterial osteomyelitis/chronic recurrent multifocal osteomyelitis and psoriasis 14, pustular, and has symptoms including arthralgia and interphalangeal joint swelling. An important gene associated with Chronic Recurrent Multifocal Osteomyelitis 2, with Periostitis and Pustulosis is IL1RN (Interleukin 1 Receptor Antagonist). The drugs Rilonacept and Interleukin 1 Receptor Antagonist Protein have been mentioned in the context of this disorder. Affiliated tissues include bone and skin, and related phenotypes are osteopenia and broad ribs