Chronic Kidney Disease, also known as chronic renal disease, is related to kidney disease and end stage renal disease, and has symptoms including cloudy (hemodialysis) (peritoneal) dialysis effluent An important gene associated with Chronic Kidney Disease is COL4A4 (Collagen Type IV Alpha 4 Chain), and among its related pathways/superpathways are Primary focal segmental glomerulosclerosis (FSGS) and Nephrotic syndrome. The drugs Simethicone and Oxycodone have been mentioned in the context of this disorder. Affiliated tissues include Bone, Adipose and kidney, and related phenotypes are homeostasis/metabolism and growth/size/body region