Chronic Lymphoproliferative Disorder of Natural Killer Cells, also known as nk-cell lineage granular lymphocyte proliferative disorder, is related to chronic nk-cell lymphocytosis and lymphoproliferative syndrome. An important gene associated with Chronic Lymphoproliferative Disorder of Natural Killer Cells is STAT3 (Signal Transducer And Activator Of Transcription 3). The drugs Prednisone and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include nk cells and skin.