Chronic Venous Insufficiency is related to venous insufficiency and varicose veins. An important gene associated with Chronic Venous Insufficiency is VCAM1 (Vascular Cell Adhesion Molecule 1), and among its related pathways/superpathways are Integrin Pathway and Response to elevated platelet cytosolic Ca2+. The drugs Hesperidin and Troxerutin have been mentioned in the context of this disorder. Affiliated tissues include skin and endothelial, and related phenotypes are homeostasis/metabolism and growth/size/body region