Chronic Purulent Otitis Media, also known as chronic suppurative otitis media, is related to tympanosclerosis and otorrhea. An important gene associated with Chronic Purulent Otitis Media is A2ML1 (Alpha-2-Macroglobulin Like 1), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and ApoE and miR-146 in inflammation and atherosclerosis. The drugs Levofloxacin and Ofloxacin have been mentioned in the context of this disorder. Affiliated tissues include bone and brain, and related phenotypes are hearing/vestibular/ear and immune system