Chronic Progressive External Ophthalmoplegia (PEO)

Chronic Progressive External Ophthalmoplegia, also known as progressive external ophthalmoplegia, is related to progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 1 and progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 1, and has symptoms including ophthalmoplegia An important gene associated with Chronic Progressive External Ophthalmoplegia is TWNK (Twinkle MtDNA Helicase), and among its related pathways/superpathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The drugs 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid and Protective Agents have been mentioned in the context of this disorder. Affiliated tissues include eye and kidney, and related phenotypes are Strongly decreased CFP-tsO45G cell surface transport and pigmentation