Chordoma, also known as notochordal sarcoma, is related to chondrosarcoma and sarcoma. An important gene associated with Chordoma is CHDM (Chordoma), and among its related pathways/superpathways are COPI-independent Golgi-to-ER retrograde traffic and Cytoskeletal Signaling. The drugs Temsirolimus and Sirolimus have been mentioned in the context of this disorder. Affiliated tissues include bone and spinal cord, and related phenotypes are chordoma and astrocytoma