Chronic Apical Periodontitis, also known as apical periodontitis nos, is related to periapical periodontitis and periodontitis. An important gene associated with Chronic Apical Periodontitis is TNFSF11 (TNF Superfamily Member 11), and among its related pathways/superpathways are Innate Immune System and Toll-like receptor signaling pathway. The drugs Thrombin and Silicon have been mentioned in the context of this disorder. Affiliated tissues include bone and t cells, and related phenotypes are immune system and mortality/aging