Cheilitis is related to crohn's disease and actinic keratosis. An important gene associated with Cheilitis is CAST (Calpastatin), and among its related pathways/superpathways are Innate Immune System and Signal Transduction. The drugs Imiquimod and Aminolevulinic acid have been mentioned in the context of this disorder. Affiliated tissues include skin and salivary gland, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Synthetic lethal with MLN4924 (a NAE inhibitor)