Childhood Disintegrative Disease, also known as childhood disintegrative disorder, is related to atypical autism and mutism. An important gene associated with Childhood Disintegrative Disease is MECP2 (Methyl-CpG Binding Protein 2), and among its related pathways/superpathways are Transmission across Chemical Synapses and Neuroscience. The drugs Metamfetamine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include brain, and related phenotypes are mental deterioration and autistic behavior