Chikungunya, also known as chikungunya fever, is related to dengue virus and zika fever, and has symptoms including fever, arthralgia and maculopapular rash. An important gene associated with Chikungunya is MXRA8 (Matrix Remodeling Associated 8), and among its related pathways/superpathways are Innate Immune System and Infectious disease. The drugs Aluminum hydroxide and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include skin and heart, and related phenotypes are fatigue and fever