Beta-Thalassemia Major

Beta-Thalassemia Major, also known as cooley's anemia, is related to hemoglobin e-beta-thalassemia syndrome and autosomal dominant beta thalassemia. An important gene associated with Beta-Thalassemia Major is HBB (Hemoglobin Subunit Beta), and among its related pathways/superpathways are Golgi-to-ER retrograde transport and Insulin receptor recycling. The drugs Metformin and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include spleen and liver, and related phenotypes are pallor and persistence of hemoglobin f