Borna Disease, also known as enzootic encephalomyelitis, is related to disease of mental health and amyotrophic lateral sclerosis 1, and has symptoms including mood disturbances, behaviour disturbances and cognitive disturbances. An important gene associated with Borna Disease is TBK1 (TANK Binding Kinase 1), and among its related pathways/superpathways are Autophagy pathway and Notch Signaling Pathway (sino). Affiliated tissues include t cells and brain.