Buerger Disease

Buerger Disease, also known as thromboangiitis obliterans, is related to takayasu arteritis and aortitis. An important gene associated with Buerger Disease is MYD88 (MYD88 Innate Immune Signal Transduction Adaptor), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Dimethyl sulfoxide and Altretamine have been mentioned in the context of this disorder. Affiliated tissues include Adipose, bone marrow and bone, and related phenotypes are skin ulcer and sensory neuropathy