Bipolar I Disorder, also known as manic-depressive illness, is related to bipolar disorder and major affective disorder 1. An important gene associated with Bipolar I Disorder is HTR2A (5-Hydroxytryptamine Receptor 2A), and among its related pathways/superpathways are CREB Pathway and Neuroscience. The drugs Oxcarbazepine and Coal tar have been mentioned in the context of this disorder. Affiliated tissues include brain and prefrontal cortex, and related phenotypes are nervous system and homeostasis/metabolism