Blue Toe Syndrome is related to cholesterol embolism and buerger disease. An important gene associated with Blue Toe Syndrome is SPECC1 (Sperm Antigen With Calponin Homology And Coiled-Coil Domains 1), and among its related pathways/superpathways are Diseases of hemostasis and Heparin-induced Thrombocytopenia Pathway, Adverse Drug Reaction. Affiliated tissues include bone marrow and skin.