Body Mass Index Quantitative Trait Locus 11, also known as obesity, is related to leptin deficiency or dysfunction and type 2 diabetes mellitus, and has symptoms including high weight, obesity, metabolically benign and monogenic obesity. An important gene associated with Body Mass Index Quantitative Trait Locus 11 is PPARG (Peroxisome Proliferator Activated Receptor Gamma), and among its related pathways/superpathways are Glucose / Energy Metabolism and Development Ligand-independent activation of ESR1 and ESR2. The drugs Metyrapone and Indapamide have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle and liver, and related phenotypes are obesity and decreased resting energy expenditure