Autism Spectrum Disorder, also known as pervasive developmental disorder, not otherwise specified, is related to autism and attention deficit-hyperactivity disorder, and has symptoms including widespread abnormalities of social interactions, severely restricted interests and highly repetitive behavior. An important gene associated with Autism Spectrum Disorder is SHANK2 (SH3 And Multiple Ankyrin Repeat Domains 2), and among its related pathways/superpathways are Neuroscience and Rett syndrome causing genes. The drugs Aripiprazole and Atomoxetine have been mentioned in the context of this disorder. Affiliated tissues include brain and eye, and related phenotypes are Decreased Aire reporter expression and Resistant to vaccinia virus (VACV-A4L) infection