Autoinflammatory Syndrome, Familial, with or Without Immunodeficiency, also known as aisimd, is related to anemia, autoimmune hemolytic and immune thrombocytopenia. An important gene associated with Autoinflammatory Syndrome, Familial, with or Without Immunodeficiency is SOCS1 (Suppressor Of Cytokine Signaling 1). Affiliated tissues include b cells and lung, and related phenotypes are decreased proportion of class-switched memory b cells and decreased proportion of marginal zone b cells