Arthrogryposis, Renal Dysfunction, and Cholestasis 1 (ARCS1)

Arthrogryposis, Renal Dysfunction, and Cholestasis 1, also known as arc syndrome, is related to arthrogryposis, renal dysfunction, and cholestasis 2 and progressive familial intrahepatic cholestasis, and has symptoms including icterus An important gene associated with Arthrogryposis, Renal Dysfunction, and Cholestasis 1 is VPS33B (VPS33B Late Endosome And Lysosome Associated), and among its related pathways/superpathways are Metabolism of proteins and Signaling by WNT. The drugs Digoxin and Ursodeoxycholic acid have been mentioned in the context of this disorder. Affiliated tissues include kidney and liver, and related phenotypes are nephrogenic diabetes insipidus and lissencephaly