Aortic Valve Insufficiency, also known as aortic regurgitation, is related to aortitis and endocarditis. An important gene associated with Aortic Valve Insufficiency is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways are Angiogenesis (CST) and SARS-CoV-2 and ACE2 receptor: molecular mechanisms. The drugs Rivaroxaban and Chlorthalidone have been mentioned in the context of this disorder. Affiliated tissues include heart and brain, and related phenotypes are muscle and homeostasis/metabolism