Aquagenic Palmoplantar Keratoderma, also known as transient reactive papulotranslucent acrokeratoderma, is related to palmoplantar keratosis and cystic fibrosis. An important gene associated with Aquagenic Palmoplantar Keratoderma is CFTR (CF Transmembrane Conductance Regulator). Affiliated tissues include skin, and related phenotypes are palmoplantar keratoderma and palmoplantar hyperhidrosis