Appendicitis, also known as acute appendicitis, is related to polyarteritis nodosa and inguinal hernia, and has symptoms including pain, nausea and vomiting. An important gene associated with Appendicitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Aztreonam and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include appendix and colon, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Reduced mammosphere formation